Preparations: Reading literature (24 hours)
Lectures and computer exercises: 18-22 August 2014 (40 hours)
Assignment, to be handed in one week after the course (8 hours)
The course will make participants familiar with the principals,
approaches and software tools used for bioprocess modelling within
the context of environmental biotechnology. They will be introduced
to biosystems analysis methods, and will be trained on selected
modelling platforms (i.e. Aquasim, COMSOL, iDynomics). The
technical training will focus on mathematical modelling of
bioengineered systems at reactor, community, cellular and
sub-cellular scales.
Læringsmål:
En studerende, der fuldt ud har opfyldt kursets mål, vil kunne:
List and discuss the principals of biokinetic processes and
their implications on engineered bioprocess operations
Describe and contrast the underlying mechanisms of the
different biochemical and physicochemical reactions relevant to
engineered water biotechnology
Develop and use steady-state mass-balance models for simple
biochemical processes (growth, decay, uptake of primary substrates)
in suspended growth and biofilm systems
Assess and discuss how basic operational conditions in
bioreactors can be set to affect microbial growth and utilization
of organic carbon, nitrogen, and phosphorous by use of mass
balances, biokinetics, stoichiometry, and hydraulic transport
processes
Compare, contrast, and apply different biokinetic descriptors
for suspended and biofilm systems
Describe and perform basic stoichiometric calculations for
biochemical unit process operations
Develop and solve –using appropriate software tools - dynamic
mass-balance models to describe biochemical processes in suspended
and biofilm systems at reactor, cellular and metabolic scales
Orally present principals and methods for the mathematical
modelling of bioprocesses in environmental biotechnology
Assess and discuss the options for incorporating the microbial
diversity in the design of wastewater treatment reactors
Solve a basic metabolic network through steady-state flux
balancing
Understand and choose the main assumptions necessary for
developing a biofilm model. Implement and solve a continuum biofilm
model based on partial differential equations in
COMSOL
Kursusindhold:
The course is developed for the fellows of the Initial Training
Network Mermaid. It should also be of interest to graduate and
postgraduate students with a life science background wishing to
model the dynamics and performance of bioreactor systems at
population and community levels.
Litteraturhenvisninger:
Gujer, W. 2008. Systems analysis for water technology.
Springer.
Mulighed for GRØN DYST deltagelse:
Kontakt underviseren for information om hvorvidt dette kursus giver
den studerende mulighed for at lave eller forberede et projekt som
kan deltage i DTUs studenterkonference om bæredygtighed,
klimateknologi og miljø (GRØN DYST). Se mere på http://www.groendyst.dtu.dk
